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Hydroxamates are physiologically active compounds. They have found applications as histone deacetylase inhibitors widely applied in cancer treatment such as.

A carbodiimide or a methanediimine is a functional group consisting of the formula RN C NR. Carbodiimides hydrolyze to form ureas, which makes them uncommon in. Carbodiimides hydrolyze to form ureas, which makes them uncommon in nature. From the perspective of small molecule activation, carbodiimides are.

The C-N C N-C core of carbodiimides N C N is linear, being related to the negatively charged oxygen must first be activated into a better leaving group. Ugwu1, Benjamin E. Ezema1, Florence U. Eze1, Jude I. Ayogu1, Chidimma G. Ezema2, Daniel I. Ugwuja3 1Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria 2National Centre for Energy Research and Development, University of Nigeria, Nsukka, Nigeria 3Department of Chemical Sciences, Federal University, Wukari, Nigeria Correspondence to: David I.

Ugwu, Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.Email: Copyright 2014 Scientific Academic Publishing. All Rights Reserved. Abstract Hydroxamates are physiologically active compounds.

They have found applications as histone deacetylase inhibitors widely applied in cancer treatment such as vorinostat, belinostat, panobinostat and trichostatin A. There are hydroxamates with reported anti-HIV activity such as the hydroxyurea which acts as inhibitors of cellular enzyme ribonucleoside diphosphate reductase. Hydroxyurea are also used for treatment of chronic myelogenal leukemia, myeloproliferative syndromes and sickle cell anemia. Hydroxamates such as fosmidomycin and desferrioxamine B are potent antimalarial agent. Eric Singer Project. Cipemastat, marimastat, periostat, ilomastat and batimastat are all hydroxamate-based inhibitors of matrix metalloproteinase and are by so used in management of cardiovascular diseases. The syntheses of various classes of hydroxamates and their mode of biological applications have been reviewed.The broad biological activities of hydroxamates and the need to improve on their synthetic routes informed the review of their synthesis and biological applications.

Keywords: Keyword Histone deacetylase inhibitors, Matrix metalloproteinase inhibitors, HIV, Hydroxamaates, Ribonucleoside diphosphate reductase Cite this paper: David I. Ugwu, Benjamin E. Ezema, Florence U. Ayogu, Chidimma G. Ezema, Daniel I. Ugwuja, Synthesis and Biological Applications of Hydroxamates, American Journal of Organic Chemistry, Vol.